Efficient RNAi-based gene family knockdown via set cover optimization
نویسندگان
چکیده
منابع مشابه
Efficient RNAi-based gene family knockdown via set cover optimization
OBJECTIVE We address the problem of selecting an efficient set of initiator molecules (siRNAs) for RNA interference (RNAi)-based gene family knockdown experiments. Our goal is to select a minimal set of siRNAs that (a) cover a targeted gene family or a specified subset of it, (b) do not cover any untargeted genes, and (c) are individually highly effective at inducing knockdown. METHODS AND MA...
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ژورنال
عنوان ژورنال: Artificial Intelligence in Medicine
سال: 2005
ISSN: 0933-3657
DOI: 10.1016/j.artmed.2005.01.009